The station opened in 1906 as Eastcote Halt and was rebuilt between 1937 and 1939 to a geometric design by Charles Holden featuring a large cube-shaped glass and brick ticket hall.

Nearby is 18th-century Highgrove House, where Winston Churchill spent his honeymoon. Eastcote also housed an outstation of the Bletchley Park codebreaking outfit during World War II.